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Background Because of the progressive nature of the disease, most patients with type 2 diabetes mellitus eventually require multiple treatments to achieve glycaemic targets. The majority of available therapies are insulin dependent, aiming to decrease insulin resistance and increase insulin secretion. Sodium glucose co-transporter 2 (SGLT2) inhibitors, a new class of antidiabetic agents, limit renal glucose reabsorption promoting urinary excretion of glucose, thereby reducing plasma glucose.

Objective/s This article explores the mechanism of action and clinical data surrounding SGLT2 inhibitors, with a particular focus on dapagli-flozin. Conclusion Clinical trials have shown dapagliflozin to be effective in reducing glycosylated haemoglobin, weight and fasting plasma glucose, either as monotherapy or as add-on therapy to metformin, sulphonylurea and insulin. Other SGLT2 inhibitors are currently under investigation.

Gallup Racer 2006 Ps2 Iso Maker. The prevalence of diabetes in Australia has increased by approximately 8% per annum since 2000. By 2017, the number of people with diabetes in Australia will be in excess of 3.6 million. 1 The multifactorial management of these patients will place an unprecedented burden on the healthcare system and society in general. 1 A major focus of diabetes management is optimal glycaemic control. 2 This involves the prevention and management of transient or sustained hyperglycaemia, as well as the avoidance of hypoglycaemia, without adversely affecting quality of life. What is ‘optimal’ glycaemic control must be individualised according to patient preferences, needs and tolerances, and considering a range of factors such as age, comorbidities, self monitoring, risk of significant side effects and complexity of treatment regimens. 2 Achieving and sustaining individual treatment goals represents the greatest fundamental challenge of diabetes care.

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3,4 The majority of patients with type 2 diabetes mellitus (T2DM) will require one or more different types of medication to manage their glucose levels. Until very recently this invariably involved the use of metformin and/or sulphonylureas. Failure of oral therapy was then followed by the introduction of basal or mixed insulins.

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Nadia - Life Of Stranger [DS DubStep Remix]. The Transporter Soundtrack - Nadia - Life of a Stranger. OST 'The Transporter' - NADIA - Life of a stranger. Nadia - Life Of A Stranger (you saved my life.) 04:44. Nadia - Life Of A Stranger ( Save my heart ).

Though effective, this strategy has a number of limitations, including beta-cell exhaustion, 5 weight gain 6 and hypoglycaemia, 7 which often lead to therapeutic inertia and compromise of targets for glycaemic control. Over the past decade, a number of new agents have been introduced for the management of diabetes. Most of the current therapies for T2DM tend to aim at decreasing insulin resistance or increasing insulin secretion ( Table 1). 5 However, a new class of drugs that enhance urinary glucose excretion, inhibiting glucose reabsorption via the sodium glucose co-transporter 2 (SGLT2), is now available.

5,7,8 Table 1. Opening or saving files Files on the website can be opened or downloaded and saved to your computer or device. To open click on the link, your computer or device will try and open the file using compatible software. To save the file right click or option-click the link and choose 'Save As.'

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These files will have 'PDF' in brackets along with the filesize of the download. To open a PDF file you will need compatible software such as Adobe Reader. If you do not have it you can. DOC Some documents on this site are in Microsoft Word format. These will have 'DOC' in brackets along with the filesize of the download. To view these documents you will need software that can read Microsoft Word format. If you don't have anything you can.

MP3 Most web browsers will play the MP3 audio within the browser. Opening or saving files Files on the website can be opened or downloaded and saved to your computer or device. To open click on the link, your computer or device will try and open the file using compatible software. To save the file right click or option-click the link and choose 'Save As.'

Follow the prompts to chose a location. Types of file PDF Most of the documents on the RACGP website are in Portable Document Format (PDF). These files will have 'PDF' in brackets along with the filesize of the download. To open a PDF file you will need compatible software such as Adobe Reader. If you do not have it you can. DOC Some documents on this site are in Microsoft Word format.

These will have 'DOC' in brackets along with the filesize of the download. To view these documents you will need software that can read Microsoft Word format. If you don't have anything you can. MP3 Most web browsers will play the MP3 audio within the browser. © The Royal Australian College of General Practitioners 2016 All rights reserved. Requests for permission to reprint articles must be sent to. The views expressed by the authors of articles in Australian Family Physician are their own and not necessarily those of the publisher or the editorial staff, and must not be quoted as such.

Every care is taken to reproduce articles accurately, but the publisher accepts no responsibility for errors, omissions or inaccuracies contained therein or for the consequences of any action taken by any person as a result of anything contained in this publication. The content of any advertising or promotional material contained within, or mailed with, Australian Family Physician is not necessarily endorsed by the publisher. .

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